Dr El Hassane Larhrib
email@example.com | 01484 473051
Dr Larhrib was educated at the University of Sciences and Technology and the Faculty of Pharmacy, Lille, France where he obtained an MSc Biochem, DU Pharm, DESS Pharm. Tech. and a certificate in Pharm. Chemistry. He moved to the UK to do a PhD at Liverpool John Moores University, using high speed compaction simulation to study the mechanism of compaction of pharmaceutical powders under the supervision of Dr. James Wells and Prof. Mike Rubinstein. Following his PhD, Dr Larhrib worked for four years as Senior Research Fellow in particle engineering and aerosol formulation & design at the Department of Pharmacy, Kings College London. He then moved to Liverpool John Moores University as a Senior Lecturer in Pharmaceutics for five years before joining Solid Solution Limited in Liverpool. He was involved in cosmetic product development and manufacture. He moved to Medway School of Pharmacy before joining the University of Huddersfield as a Senior Lecturer in Pharmaceutics in July 2011.
Research and Scholarship
- Mechanism of compaction of pharmaceutical powders.
- Particle Engineering to enhance therapeutic value of medicines.
- Pulmonary drug delivery: Formulation design to maximise drug delivery to the lungs.
- Skin care product development using natural and certified organic ingredients
Publications and Other Research Outputs
Abadelah, M., Chrystyn, H., Bagherisadeghi, G., Abdalla, G. and Larhrib, H. (2017) ‘Study of the Emitted Dose After Two Separate Inhalations at Different Inhalation Flow Rates and Volumes and an Assessment of Aerodynamic Characteristics of Indacaterol Onbrez Breezhaler® 150 and 300 ?g’ AAPS PharmSciTech . ISSN 1530-9932
Nikander, K., von Hollen, D. and Larhrib, H. (2016) ‘The size and behavior of the human upper airway during inhalation of aerosols’ Expert Opinion on Drug Delivery , pp. 1-10. ISSN 1742-5247
Larhrib, E., Bagherisadeghi, G. and Chrystyn, H. (2015) ‘Dose emission from a combination turbuhaler using patient inhalation profiles’. In: International Society for Aerosols in Medicine ISAM Congress, 30th May - 03rd June 2015, Munich, Germany , p. 45
Larhrib, E., Gombakomba, L., Thakrar, A. and Chrystyn, H. (2015) ‘Training patients to improve their inhalation manouvre when using different dry powder inhalers (DPIS)’. In: International Society for Aerosols in Medicine ISAM Congress, 30th May - 03rd June 2015, Munich, Germany , p. 50
Larhrib, E., Jones, H., Rawson, S. and Chrystyn, H. (2015) ‘Train patients to prolong their inhalation manouvre when using a meter dose inhaler’. In: International Society for Aerosols in Medicine ISAM Congress, 30th May - 03rd June 2015, Munich, Germany , p. 27
Asare-Addo, K., Conway, B., Hajamohaideen, M., Kaialy, W., Nokhodchi, A. and Larhrib, E. (2013) ‘Aqueous And Hydro-Alcoholic Media Effects On Polyols’ Colloids and Surfaces B: Biointerfaces , 111, pp. 24-29. ISSN 0927-7765
Nokhodchi, A. and Larhrib, H. (2013) ‘Overcoming the undesirable properties of dry-powder inhalers with novel engineered mannitol particles’ Therapeutic Delivery , 4 (8), pp. 879-882. ISSN 2041-5990
Kaialy, W., Larhrib, E., Martin, G. and Nokhodchi, A. (2012) ‘The Effect of Engineered Mannitol-Lactose Mixture on Dry Powder Inhaler Performance’ Pharmaceutical Research , 29 (8), pp. 2139-2156. ISSN 0724-8741
Kaialy, W., Larhrib, E., Ticehurst, M. and Nokhodchi, A. (2012) ‘Influence of Batch Cooling Crystallization on Mannitol Physical Properties and Drug Dispersion from Dry Powder Inhalers’ Crystal Growth & Design , 12 (6), pp. 3006-3017. ISSN 1528-7483
Kaialy, W., Larhrib, E. and Nokhodchi, A. (2012) ‘The effect of carrier particle size on adhesion, content uniformity and inhalation performance of budesonide using dry powder inhalers’. In: Particulate Materials: Synthesis, Characterisation, Processing and Modelling. London, UK: The Royal Society of Chemistry. pp. 113-119. ISBN 978-1-84973-514-8
Kaialy, W., Martin, G., Larhrib, E., Ticehurst, M., Kolosionek, E. and Nokhodchi, A. (2012) ‘The influence of physical properties and morphology of crystallised lactose on delivery of salbutamol sulphate from dry powder inhalers’ Colloids and Surfaces B: Biointerfaces , 89, pp. 29-39. ISSN 09277765
Research Degree Supervision
Self funded PhD candidates are welcomed to apply in the following research areas:
- Engineering drug co-crystals for pulmonary drug delivery. Physicochemical characterisation, formulation and drug delivery in-vitro.
- Nano-Co-crystal engineering to improve the solubility and bioavailability of poorly water soluble drugs.
- Engineering long time-of-flight carrier particles for improved drug deposition to the lungs.
- Use of freeze fracturing technique developed in house to engineer low density, aerodynamic drug particles for inhalation.
- Engineering spherical crystals of drugs and excipients for tablet direct compression.
- Developing topical formulations containing a botanical complex for treating skin conditions: dermatitis, eczema, psoriasis and acne.
Applications are welcomed from potential students with an interest in skin delivery, particle engineering, formulation design and delivery in-vitro of inhaled products, mechanism of compaction of pharmaceutical powders.